Influence of different hypoxia types on p-glycoprotein functional activity and expression
نویسندگان
چکیده
منابع مشابه
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15 صفحه اولexistence and approximate $l^{p}$ and continuous solution of nonlinear integral equations of the hammerstein and volterra types
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The activity of cytochrome p450 isozyme 3A4 (CYP3A4) enzyme and P-glycoprotein (P-gp) is modulated by grapefruit juice and herbal drugs. CYP3A4 is the major phase I drug metabolizing enzyme and P-gp is an ATP-dependent drug efflux pump that regulates the intestinal absorption of orally administered drugs. Honey is commonly consumed as a dietary supplement. However, its influence on human CY...
متن کاملExpression and functional activity of P-glycoprotein in cultured hepatocytes from Oncorhynchus mykiss.
P-glycoproteins encoded by multidrug resistance 1 (mdr1) genes are ATP-dependent transporters located in the plasma membrane that mediate the extrusion of hydrophobic compounds from the cell. Using cultured isolated rainbow trout hepatocytes, we characterized an mdr1-like transport mechanism of the teleost liver. Immunoblots with the monoclonal antibody C219, which recognizes a conserved epitop...
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ژورنال
عنوان ژورنال: Reviews on Clinical Pharmacology and Drug Therapy
سال: 2016
ISSN: 2542-1875,1683-4100
DOI: 10.17816/rcf14171-77